Testosterone and ED: Effective Treatments and Natural Solutions

Testosterone and ED: Effective Treatments and Natural Solutions

Introduction

Erectile dysfunction (ED) is a common condition that affects many men worldwide. It is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. The prevalence of ED increases with age, but it can affect men of all ages. ED can have significant effects on a man's physical and mental health, impacting self-esteem, relationships, and overall quality of life.

Testosterone, the primary male sex hormone, plays a vital role in male sexual health. It influences libido, mood, and erectile function. Testosterone levels naturally decline with age, which can contribute to the development of ED. However, low testosterone levels are not the only cause of ED. Other factors, including cardiovascular diseases, diabetes, obesity, and psychological issues, can also contribute to the condition.

Understanding the relationship between testosterone and ED is crucial for effective treatment. While testosterone replacement therapy (TRT) can help some men with low testosterone levels, it is not always the best solution for everyone. There are various other medical treatments, lifestyle changes, and natural solutions that can help manage ED.

This article aims to provide a comprehensive overview of the relationship between testosterone and ED, exploring effective treatments and natural solutions. It will cover the basics of ED, the role of testosterone in male sexual health, the causes of low testosterone, and how it is diagnosed. The article will also discuss medical treatments for low testosterone and ED, lifestyle changes to improve testosterone levels, and natural supplements. Additionally, it will address the psychological and emotional factors that can contribute to ED and highlight emerging treatments and research in the field.

The first step in managing ED is understanding the condition itself. ED is often a symptom of an underlying health issue. Common causes include cardiovascular diseases, which affect blood flow to the penis, and diabetes, which can damage nerves and blood vessels. Obesity and a sedentary lifestyle are also significant risk factors. Psychological factors, such as stress, anxiety, and depression, can further exacerbate the condition. By addressing these underlying issues, men can improve their overall health and reduce the severity of ED.

Testosterone plays a crucial role in male sexual health. It is responsible for the development of male sexual characteristics, such as facial hair and a deep voice, and it influences libido and erectile function. Normal testosterone levels vary with age but generally range between 300 and 1,000 nanograms per deciliter (ng/dL). Low testosterone levels, or hypogonadism, can lead to reduced libido, fatigue, and ED. It is important to understand that while low testosterone can contribute to ED, it is not the sole cause. Other factors must also be considered when diagnosing and treating ED.

Diagnosing low testosterone involves a thorough clinical evaluation and laboratory tests. Symptoms of low testosterone include reduced libido, erectile dysfunction, fatigue, and loss of muscle mass. Blood tests are used to measure testosterone levels, and imaging studies may be conducted to identify any underlying causes. Differentiating between primary and secondary causes of low testosterone is crucial for effective treatment. Primary hypogonadism is caused by problems in the testes, while secondary hypogonadism is due to issues in the hypothalamus or pituitary gland.

Medical treatments for low testosterone and ED include testosterone replacement therapy (TRT) and phosphodiesterase type 5 inhibitors (PDE5 inhibitors). TRT involves administering testosterone through injections, gels, patches, or other methods to restore normal levels. While TRT can be effective, it is not suitable for everyone and may have side effects. PDE5 inhibitors, such as Viagra, Cialis, and Levitra, work by increasing blood flow to the penis, helping to achieve and maintain an erection. These medications are effective for many men but may not address the underlying causes of ED.

Lifestyle changes are essential for improving testosterone levels and managing ED. A balanced diet rich in essential nutrients can boost testosterone production. Regular physical activity, particularly strength training, can also enhance testosterone levels and improve overall health. Weight management is crucial, as obesity can negatively impact testosterone levels and contribute to ED. Maintaining a healthy weight through diet and exercise can help improve sexual function.

Natural supplements, such as herbal remedies and vitamins, can also play a role in managing low testosterone and ED. Herbal remedies like ginseng, fenugreek, and ashwagandha have been shown to boost testosterone levels. Vitamins and minerals, including vitamin D, zinc, and magnesium, are essential for testosterone production and overall health. While these supplements can be beneficial, it is important to use them under medical supervision to avoid potential side effects and interactions with other medications.

Psychological and emotional factors can significantly impact ED. Stress, anxiety, and depression can reduce libido and erectile function. Addressing these factors through counseling, stress management techniques, and lifestyle changes can help improve sexual health. Understanding the psychological contributors to ED is crucial for a holistic approach to treatment.

Emerging treatments and research in the field of ED and low testosterone offer hope for new and effective therapies. Advances in medical treatments, experimental therapies, and ongoing research are continually expanding our understanding of these conditions. Staying informed about these developments can help men and their healthcare providers make better decisions about treatment options.

Preventive measures and long-term management strategies are essential for maintaining sexual health and overall well-being. Regular medical check-ups, a healthy lifestyle, and proactive management of underlying health conditions can help prevent ED and maintain normal testosterone levels.

In conclusion, understanding the relationship between testosterone and ED is crucial for effective treatment. By addressing both medical and lifestyle factors, men can improve their sexual health and overall quality of life. Seeking medical advice and exploring a comprehensive approach to treatment can provide the best outcomes for men with ED and low testosterone.

Understanding Erectile Dysfunction (ED)

Erectile dysfunction (ED) is a common condition affecting many men. ED is when a man cannot get or keep an erection firm enough for sexual intercourse. This condition can be frustrating and embarrassing, but it is essential to understand that it is a common problem and can be treated.

Definition and Prevalence of ED

Erectile dysfunction, often known as impotence, is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It can affect men of all ages but becomes more common as men get older. According to the American Urological Association, ED affects about 30 million men in the United States. It is estimated that about 50% of men aged 40 to 70 experience some degree of ED at some point in their lives.

Common Causes and Risk Factors

Several factors can cause ED, and they can be physical, psychological, or a combination of both. Understanding these causes is vital for effective treatment.

Physical Causes:

  1. Cardiovascular Disease: Poor heart health can reduce blood flow to the penis, making it difficult to achieve an erection.
  2. Diabetes: High blood sugar levels can damage blood vessels and nerves that control erection.
  3. High Blood Pressure: This can damage the arteries, reducing blood flow to the penis.
  4. High Cholesterol: Like high blood pressure, high cholesterol can block blood flow in the arteries.
  5. Obesity: Excess weight can lead to diabetes and cardiovascular disease, both risk factors for ED.
  6. Hormonal Imbalances: Low levels of testosterone can affect sexual desire and performance.
  7. Neurological Disorders: Conditions such as Parkinson's disease, multiple sclerosis, and spinal cord injuries can interfere with nerve signals between the brain and the penis.
  8. Medications: Some medications can cause ED as a side effect. These include drugs for high blood pressure, depression, and anxiety.
  9. Substance Abuse: Alcohol, tobacco, and illegal drugs can impair blood flow and nerve function.

Psychological Causes:

  1. Stress: Stress about work, finances, or other life issues can affect sexual performance.
  2. Anxiety: Worrying about sexual performance can make it harder to achieve an erection.
  3. Depression: This condition can reduce sexual desire and lead to ED.
  4. Relationship Issues: Poor communication or unresolved conflicts with a partner can cause or worsen ED.

Impact of ED on Physical and Mental Health

Erectile dysfunction can significantly impact a man's quality of life. Physically, it may be a sign of underlying health problems that need treatment, such as heart disease or diabetes. Men with ED should see a doctor to check for these conditions.

Mentally, ED can affect self-esteem and confidence. It can lead to anxiety and depression, which can, in turn, make ED worse. The stress and frustration from ED can also cause problems in relationships, leading to feelings of inadequacy and isolation.

Importance of Seeking Help

Many men feel embarrassed to talk about ED, but it is important to seek help. ED is a medical condition that doctors are used to treating. Many effective treatments are available, and in many cases, addressing the underlying cause can improve ED.

Treatment can involve lifestyle changes, medications, or therapy. Lifestyle changes include losing weight, exercising, quitting smoking, and reducing alcohol intake. Medications such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) can help improve blood flow to the penis. In some cases, psychological counseling or therapy can address stress, anxiety, or depression contributing to ED.

Erectile dysfunction is a common condition that can affect men of all ages, especially as they get older. Understanding the causes and seeking appropriate treatment can help manage and improve ED, leading to better overall health and quality of life. If you or someone you know is experiencing ED, do not hesitate to seek medical advice. There is no need to suffer in silence, as help is available.

testosterone for ed 2

Role of Testosterone in Male Sexual Health

Testosterone is a vital hormone in the male body. It plays a key role in many functions, especially in sexual health. Understanding how testosterone works can help explain its impact on erectile dysfunction (ED) and overall well-being.

Functions of Testosterone in the Male Body

Testosterone is often called the "male hormone." It is produced mainly in the testicles and a small amount in the adrenal glands. This hormone is crucial for:

  1. Development During Puberty: During puberty, testosterone levels rise sharply. This surge leads to the development of secondary sexual characteristics. Boys grow facial and body hair, their voices deepen, and their muscles and bones become stronger.
  2. Maintaining Muscle Mass and Strength: Testosterone helps maintain muscle mass and strength. It promotes the growth of muscle tissue, which is important for physical fitness and overall health.
  3. Bone Density: Testosterone supports bone density, reducing the risk of fractures and osteoporosis. Strong bones are essential for supporting the body and protecting internal organs.
  4. Red Blood Cell Production: This hormone aids in the production of red blood cells, which carry oxygen throughout the body. Adequate oxygen levels are necessary for energy and overall vitality.
  5. Fat Distribution: Testosterone influences how the body stores fat. Men with healthy testosterone levels are less likely to accumulate excess fat, especially around the abdomen.
  6. Mood and Cognitive Function: Testosterone impacts mood and cognitive abilities. Low levels of testosterone can lead to mood swings, depression, and difficulties with concentration and memory.

How Testosterone Affects Libido and Erectile Function

Testosterone is crucial for sexual desire (libido) and erectile function. Here's how:

  1. Libido: Testosterone is directly linked to sex drive. Men with higher levels of testosterone tend to have a stronger desire for sexual activity. Conversely, low levels can result in a decreased interest in sex.
  2. Erectile Function: While testosterone is not the sole factor in achieving an erection, it plays a significant role. Erections are caused by a complex interaction of hormones, nerves, muscles, and blood vessels. Testosterone helps stimulate receptors in the brain to produce nitric oxide, a molecule that triggers the erection process.
  3. Sperm Production: Testosterone is essential for the production of sperm. Healthy sperm production is critical for fertility.

Normal Testosterone Levels and How They Change with Age

Testosterone levels can vary widely among individuals. However, there are standard ranges considered normal:

  1. Normal Levels: For adult men, normal testosterone levels typically range from 300 to 1,000 nanograms per deciliter (ng/dL). Levels can be influenced by various factors, including age, health, and lifestyle.
  2. Age-Related Decline: Testosterone levels peak during adolescence and early adulthood. After the age of 30, they gradually decline at a rate of about 1% per year. By the time a man reaches his 70s, his testosterone levels may be about 30% lower than when he was younger.
  3. Impact of Low Testosterone: Low testosterone, also known as hypogonadism, can have significant effects on health. Symptoms of low testosterone include reduced libido, erectile dysfunction, fatigue, depression, loss of muscle mass, and increased body fat. It can also lead to decreased bone density and anemia.

Factors Affecting Testosterone Levels

Several factors can influence testosterone levels:

  1. Health Conditions: Conditions such as diabetes, obesity, and metabolic syndrome can lower testosterone levels. Certain medications and treatments, like chemotherapy, can also impact hormone levels.
  2. Lifestyle Choices: Poor diet, lack of exercise, and chronic stress can negatively affect testosterone production. On the other hand, a healthy lifestyle with regular physical activity and a balanced diet can help maintain normal levels.
  3. Sleep: Quality sleep is vital for hormone production. Lack of sleep or sleep disorders like sleep apnea can reduce testosterone levels.
  4. Alcohol and Drug Use: Excessive alcohol consumption and drug use can impair the body's ability to produce testosterone.

Understanding the role of testosterone in male sexual health is essential for recognizing its impact on erectile function and overall well-being. Maintaining healthy testosterone levels through lifestyle choices and medical interventions can improve both physical and mental health.

Causes of Low Testosterone

Low testosterone, or hypogonadism, is a condition where the body doesn't produce enough of the hormone testosterone. This can affect men at any age and has various causes. Understanding these causes can help in managing and treating the condition effectively.

Primary and Secondary Hypogonadism

Primary Hypogonadism
Primary hypogonadism, also known as primary testicular failure, occurs when the testicles themselves do not produce enough testosterone. This can be due to genetic conditions, damage to the testicles, or other factors. Common causes include:

  • Klinefelter Syndrome: A genetic disorder where males have an extra X chromosome, which affects the development of the testicles.
  • Undescended Testicles: In some boys, one or both testicles fail to descend into the scrotum before birth. If not corrected early, this can lead to reduced testosterone production.
  • Mumps Orchitis: A mumps infection involving the testicles that can cause lasting damage and affect testosterone production.
  • Hemochromatosis: A condition where the body has too much iron, which can damage the testicles and other organs.
  • Injury to the Testicles: Physical trauma or injury to the testicles can impair their ability to produce testosterone.
  • Cancer Treatment: Radiation or chemotherapy can affect the testicles and reduce testosterone production.

Secondary Hypogonadism
Secondary hypogonadism occurs when there is a problem with the hypothalamus or the pituitary gland—parts of the brain that signal the testicles to produce testosterone. Causes include:

  • Pituitary Disorders: Conditions like pituitary tumors can interfere with hormone production.
  • Kallmann Syndrome: A genetic disorder where the hypothalamus does not function properly.
  • Inflammatory Diseases: Conditions like sarcoidosis, tuberculosis, or histiocytosis can affect the pituitary gland and hypothalamus.
  • Medications: Certain drugs, such as opioids or steroids, can impact the functioning of the hypothalamus and pituitary gland.
  • Obesity: Excess body fat can affect hormone levels and disrupt the normal function of the hypothalamus and pituitary gland.
  • Chronic Illnesses: Conditions like HIV/AIDS can interfere with hormone production and regulation.

Medical Conditions and Lifestyle Factors Leading to Low Testosterone

Several medical conditions and lifestyle factors can lead to low testosterone levels. Understanding these can help in managing the condition better.

Medical Conditions

  • Type 2 Diabetes: There is a strong link between diabetes and low testosterone levels. Insulin resistance can affect hormone production.
  • Liver and Kidney Disease: Chronic liver and kidney diseases can impact hormone levels.
  • Sleep Apnea: This condition can disrupt hormone production and lead to low testosterone levels.
  • Metabolic Syndrome: A cluster of conditions that increase the risk of heart disease, stroke, and diabetes can also affect testosterone levels.

Lifestyle Factors

  • Poor Diet: Diets high in processed foods, sugars, and unhealthy fats can lead to obesity and hormonal imbalances.
  • Lack of Exercise: Physical inactivity can contribute to obesity and low testosterone levels.
  • Stress: Chronic stress can lead to elevated levels of cortisol, a hormone that can negatively impact testosterone production.
  • Alcohol and Drug Use: Excessive alcohol consumption and drug abuse can damage the testicles and liver, affecting testosterone production.

Symptoms of Low Testosterone

Recognizing the symptoms of low testosterone is crucial for early diagnosis and treatment. Common symptoms include:

  • Reduced Sex Drive: A noticeable decrease in libido or interest in sex.
  • Erectile Dysfunction: Difficulty achieving or maintaining an erection.
  • Fatigue and Low Energy Levels: Persistent tiredness despite adequate rest.
  • Loss of Muscle Mass: A decrease in muscle strength and size.
  • Increased Body Fat: Particularly around the abdomen.
  • Mood Changes: Feelings of depression, irritability, or anxiety.
  • Reduced Bone Density: Increased risk of fractures and osteoporosis.
  • Decreased Body Hair: Loss of facial and body hair.

Understanding the causes of low testosterone is the first step in addressing the condition. By identifying and addressing the underlying issues, men can improve their hormone levels and overall health. If you suspect you have low testosterone, consult with a healthcare provider for proper diagnosis and treatment.

Diagnosing Low Testosterone and ED

Erectile dysfunction (ED) and low testosterone levels can have a significant impact on a man’s life. Proper diagnosis is crucial to finding the right treatment. This section will explain the symptoms, clinical evaluation, laboratory tests, imaging studies, and how to differentiate between primary and secondary causes of low testosterone.

Symptoms and Clinical Evaluation

When a man visits a doctor for ED or suspected low testosterone, the first step is to discuss his symptoms. Symptoms of low testosterone can include:

  • Reduced sex drive
  • Difficulty achieving or maintaining an erection
  • Low energy and fatigue
  • Depression or mood changes
  • Decreased muscle mass
  • Increased body fat
  • Loss of body hair

The doctor will also ask about the patient's medical history. This includes any past illnesses, surgeries, and medications that could affect testosterone levels. The patient may be asked about lifestyle factors like diet, exercise, alcohol use, and smoking. All these factors can contribute to low testosterone and ED.

Laboratory Tests

The next step in diagnosing low testosterone is blood tests. Blood tests measure the amount of testosterone in the blood. The best time to take these tests is in the morning when testosterone levels are highest. The main tests include:

  • Total Testosterone: This measures the total amount of testosterone in the blood. Normal levels range from 300 to 1,000 ng/dL (nanograms per deciliter). Levels below 300 ng/dL usually indicate low testosterone.
  • Free Testosterone: This measures the testosterone not bound to proteins in the blood. This is a smaller portion of the total testosterone but is important for understanding how much testosterone is available for the body to use.

Other tests may be needed to understand the cause of low testosterone:

  • Luteinizing Hormone (LH): This hormone stimulates the testes to produce testosterone. Low levels of LH may indicate a problem with the pituitary gland, which produces LH.
  • Follicle-Stimulating Hormone (FSH): This helps control sperm production. It can be tested if fertility is a concern.
  • Prolactin: High levels of this hormone can indicate problems with the pituitary gland.

Imaging Studies

In some cases, imaging studies are needed to get a better understanding of what is causing low testosterone. These might include:

  • Pituitary MRI: This is an imaging test that looks at the pituitary gland in the brain. It can help find tumors or other issues that might affect hormone production.
  • Testicular Ultrasound: This can check for problems in the testes, such as tumors, that could affect testosterone production.

Differentiating Between Primary and Secondary Causes

It is important to determine if low testosterone is due to primary or secondary hypogonadism.

  • Primary Hypogonadism: This is when the problem originates in the testes. Causes can include:
    • Genetic disorders like Klinefelter syndrome
    • Testicular injury or infection
    • Chemotherapy or radiation treatment
  • Secondary Hypogonadism: This is when the problem originates in the pituitary gland or hypothalamus. Causes can include:
    • Pituitary disorders or tumors
    • Hypothalamic disease
    • Chronic illness or obesity

Doctors use the results from symptoms, clinical evaluation, blood tests, and imaging studies to identify whether the cause is primary or secondary. For example, if both LH and FSH are low or normal but testosterone is low, it may indicate secondary hypogonadism. Conversely, high levels of LH and FSH with low testosterone suggest primary hypogonadism.

Diagnosing low testosterone and ED involves a thorough examination of symptoms, medical history, and a series of tests. Blood tests are crucial in determining testosterone levels, while imaging studies help in identifying any underlying issues in the testes or pituitary gland. Differentiating between primary and secondary causes is essential for effective treatment. Accurate diagnosis paves the way for tailored treatments that can significantly improve a patient’s quality of life.

testosterone for ed 3

Medical Treatments for Low Testosterone and ED

Erectile dysfunction (ED) and low testosterone can significantly impact a man’s quality of life. Medical treatments are available to address these issues effectively. This section will cover Testosterone Replacement Therapy (TRT), Phosphodiesterase type 5 inhibitors (PDE5 inhibitors), and combination therapies in detail.

Testosterone Replacement Therapy (TRT)

Testosterone Replacement Therapy (TRT) is a common treatment for men with low testosterone levels. TRT helps to restore normal testosterone levels, which can improve energy, mood, and sexual function.

Types of TRT

  1. Injections: Testosterone injections are administered into the muscle. They are usually given every one to two weeks. This method allows testosterone to be absorbed directly into the bloodstream.
  2. Gels: Testosterone gels are applied to the skin, usually on the shoulders or arms. The hormone is absorbed through the skin into the bloodstream. Gels need to be applied daily and care must be taken to avoid skin contact with others to prevent accidental exposure.
  3. Patches: Testosterone patches are applied to the skin. They release testosterone slowly into the body over 24 hours. Patches are typically worn on the back, abdomen, upper arms, or thighs.
  4. Pellets: Testosterone pellets are small implants inserted under the skin, typically in the hip area. These pellets release testosterone slowly over three to six months.

Efficacy and Safety

TRT is effective in raising testosterone levels to the normal range. Men undergoing TRT often report improvements in sexual function, energy levels, and mood. However, TRT is not without risks. Potential side effects include:

  • Acne and oily skin
  • Increased red blood cell count, which can lead to blood clots
  • Breast enlargement or tenderness
  • Sleep apnea
  • Potential impact on fertility

It is crucial to have regular follow-up appointments with a healthcare provider to monitor testosterone levels and adjust the treatment as needed.

Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)

PDE5 inhibitors are another primary treatment for ED. These medications help to enhance the effects of nitric oxide, a natural chemical the body produces that relaxes muscles in the penis. This increases blood flow and helps to achieve and maintain an erection.

Common Medications

  1. Viagra (Sildenafil): One of the most well-known ED medications, Viagra is taken about 30 minutes to an hour before sexual activity. Its effects can last up to four hours.
  2. Cialis (Tadalafil): Cialis can be taken as needed or daily. When taken as needed, it should be taken at least 30 minutes before sexual activity, with effects lasting up to 36 hours. Daily dosing allows for more spontaneous sexual activity.
  3. Levitra (Vardenafil): Levitra is taken about 60 minutes before sexual activity. Its effects last for about four to five hours.
  4. Stendra (Avanafil): Stendra can be taken 15-30 minutes before sexual activity, with effects lasting up to six hours.

Mechanism of Action and Effectiveness

PDE5 inhibitors work by blocking the enzyme phosphodiesterase type 5, which can interfere with erectile function. By inhibiting this enzyme, these medications help to maintain higher levels of cyclic guanosine monophosphate (cGMP), which promotes muscle relaxation and increased blood flow to the penis. PDE5 inhibitors are generally effective and safe for most men, but they require sexual stimulation to work and are not an aphrodisiac.

Potential Side Effects

  • Headaches
  • Flushing
  • Indigestion
  • Nasal congestion
  • Dizziness
  • Visual disturbances

Men taking nitrates for heart conditions should not use PDE5 inhibitors due to the risk of severe blood pressure drops.

Combination Therapies

In some cases, a combination of treatments may be the most effective approach. For example, a man may use both TRT and a PDE5 inhibitor if one treatment alone is not sufficient. Combination therapies should always be managed by a healthcare provider to ensure safety and effectiveness.

Benefits of Combination Therapy

  • Enhanced Effectiveness: Combining TRT and PDE5 inhibitors can address both low testosterone levels and the physiological aspects of ED.
  • Personalized Treatment: Combination therapy allows for a more tailored approach, addressing multiple underlying causes of ED.

Monitoring and Adjustments

Combination therapies require careful monitoring. Regular check-ups with a healthcare provider are necessary to ensure the treatments are working effectively and to adjust dosages as needed.

Medical treatments for low testosterone and ED offer various options, including TRT, PDE5 inhibitors, and combination therapies. Each treatment has its benefits and potential risks, so it is crucial to work with a healthcare provider to determine the best approach for individual needs.

Lifestyle Changes to Improve Testosterone Levels and ED

When it comes to improving testosterone levels and managing erectile dysfunction (ED), lifestyle changes can make a big difference. By adopting healthy habits, you can naturally boost your testosterone levels and enhance your sexual health. Here are some key areas to focus on:

Diet and Nutrition

Foods that Boost Testosterone 

Eating the right foods can help increase your testosterone levels. Here are some foods to include in your diet:

  • Lean Proteins: Chicken, turkey, and lean cuts of beef are good sources of protein, which is essential for testosterone production.
  • Fatty Fish: Salmon, mackerel, and sardines are rich in omega-3 fatty acids, which can boost testosterone.
  • Eggs: Eggs are high in protein and cholesterol, both of which are important for testosterone production.
  • Nuts and Seeds: Almonds, walnuts, and sunflower seeds are great for increasing testosterone levels due to their high zinc content.
  • Leafy Greens: Spinach, kale, and Swiss chard contain magnesium, which can help boost testosterone.

Importance of a Balanced Diet 

Eating a balanced diet is crucial for overall health and can help maintain healthy testosterone levels. This means eating a variety of foods from all the food groups, including:

  • Fruits and Vegetables: Aim for at least five servings a day to ensure you get plenty of vitamins and minerals.
  • Whole Grains: Choose whole grains like brown rice, quinoa, and whole wheat bread instead of refined grains.
  • Healthy Fats: Include sources of healthy fats, such as avocados, olive oil, and nuts.
  • Lean Proteins: Incorporate lean proteins into your meals, such as chicken, fish, and beans.

Exercise and Physical Activity

Types of Exercise that Enhance Testosterone 

Regular physical activity is one of the best ways to boost testosterone levels. Here are some types of exercises that are particularly effective:

  • Strength Training: Lifting weights or using resistance bands can help increase testosterone levels. Aim for at least two strength-training sessions per week.
  • High-Intensity Interval Training (HIIT): This involves short bursts of intense exercise followed by rest periods. HIIT has been shown to boost testosterone levels.
  • Cardiovascular Exercise: Activities like running, swimming, and cycling can also help maintain healthy testosterone levels.

Benefits of Regular Physical Activity 

Engaging in regular physical activity has numerous benefits for your overall health and well-being:

  • Weight Management: Exercise helps you maintain a healthy weight, which is important because obesity can lower testosterone levels.
  • Improved Mood: Physical activity releases endorphins, which can help reduce stress and improve your mood.
  • Increased Energy Levels: Regular exercise can boost your energy levels and reduce fatigue.
  • Better Sleep: Being physically active can help you sleep better, which is important for maintaining healthy testosterone levels.

Weight Management

Impact of Obesity on Testosterone and ED 

Carrying excess weight can negatively affect your testosterone levels and increase your risk of ED. Here’s how:

  • Hormonal Imbalance: Obesity can lead to a decrease in testosterone and an increase in estrogen, a hormone that can counteract the effects of testosterone.
  • Inflammation: Excess fat tissue can cause inflammation, which can reduce testosterone levels.
  • Insulin Resistance: Obesity can lead to insulin resistance, which is linked to lower testosterone levels.

Strategies for Healthy Weight Loss 

Losing weight can help boost your testosterone levels and improve your sexual health. Here are some strategies to consider:

  • Healthy Eating: Focus on eating a balanced diet with plenty of fruits, vegetables, lean proteins, and whole grains. Avoid processed foods, sugary drinks, and excessive amounts of unhealthy fats.
  • Regular Exercise: Incorporate both strength training and cardiovascular exercise into your routine. Aim for at least 150 minutes of moderate-intensity exercise per week.
  • Stay Hydrated: Drink plenty of water throughout the day to stay hydrated and support your body’s functions.
  • Set Realistic Goals: Aim for a gradual weight loss of 1-2 pounds per week. Rapid weight loss can be unhealthy and unsustainable.
  • Seek Support: Consider joining a weight loss group or working with a healthcare professional to stay motivated and on track.

By making these lifestyle changes, you can naturally boost your testosterone levels and improve your sexual health. Remember, it’s important to be consistent and patient, as it may take time to see significant results. Always consult with your healthcare provider before starting any new diet or exercise program to ensure it’s safe and appropriate for you.

Natural Supplements for Testosterone and ED

Natural supplements have become popular among men looking to boost their testosterone levels and improve erectile dysfunction (ED). These supplements are often derived from herbs, vitamins, and minerals, and are seen as a safer alternative to pharmaceuticals. In this section, we will explore some of the most commonly used natural supplements and their effectiveness and safety.

Herbal Remedies

Ginseng

Ginseng, particularly Korean red ginseng, is one of the most well-known herbal remedies for enhancing sexual function and increasing testosterone. Studies have shown that ginseng can improve erectile function and boost libido. It is believed to work by increasing nitric oxide levels in the blood, which helps relax the muscles in the penis and improves blood flow. Regular use of ginseng may lead to better erections and enhanced sexual performance.

Fenugreek

Fenugreek is another popular herb known for its testosterone-boosting properties. It contains compounds called saponins, which are thought to stimulate testosterone production. Research indicates that fenugreek can help increase libido, improve sexual performance, and may also have positive effects on muscle mass and strength. It is commonly found in supplements designed to enhance male health.

Ashwagandha

Ashwagandha, an adaptogenic herb, has been used in traditional medicine for centuries. It is known for its ability to reduce stress and improve overall well-being. Recent studies suggest that ashwagandha can also increase testosterone levels and improve sperm quality. By reducing stress, which can negatively affect testosterone production, ashwagandha may indirectly support better sexual health and erectile function.

Vitamins and Minerals

Vitamin D

Vitamin D is essential for overall health, and its deficiency is linked to lower testosterone levels. Exposure to sunlight is the primary source of vitamin D, but it can also be taken as a supplement. Studies have shown that men with higher levels of vitamin D tend to have higher testosterone levels. Taking vitamin D supplements can help improve testosterone production, especially in those with a deficiency.

Zinc

Zinc is a crucial mineral for testosterone production. It plays a significant role in regulating serum testosterone levels in healthy men. Zinc deficiency can lead to hypogonadism, a condition characterized by low testosterone levels. Supplementing with zinc can help restore normal testosterone levels and improve sexual function. Foods rich in zinc, like oysters, meat, and nuts, are also beneficial.

Magnesium

Magnesium is another mineral that supports healthy testosterone levels. It helps regulate various biochemical reactions in the body, including testosterone production. Studies have indicated that magnesium supplementation can increase free and total testosterone levels in both athletes and sedentary individuals. Including magnesium-rich foods like leafy greens, nuts, and whole grains in your diet can also help.

Efficacy and Safety of Natural Supplements

While natural supplements offer potential benefits, their effectiveness can vary from person to person. It is important to choose high-quality supplements from reputable brands and consult with a healthcare provider before starting any new supplement regimen.

Benefits

  • Non-Invasive: Natural supplements are typically taken orally and do not require medical procedures.
  • Fewer Side Effects: Compared to synthetic medications, natural supplements often have fewer side effects.
  • Overall Health Improvement: Many natural supplements provide additional health benefits beyond testosterone boosting, such as improved mood, better sleep, and increased energy levels.

Considerations

  • Quality and Purity: The supplement industry is not strictly regulated, so the quality and purity of products can vary. Look for supplements that are third-party tested for quality assurance.
  • Interactions with Medications: Some natural supplements can interact with medications. It is important to discuss with your doctor, especially if you are taking other treatments.
  • Individual Responses: The effectiveness of natural supplements can differ based on individual health conditions, lifestyle, and genetic factors.

Natural supplements like herbal remedies and essential vitamins and minerals can play a significant role in boosting testosterone levels and improving erectile function. However, it is crucial to approach these supplements with caution and professional guidance to ensure safety and effectiveness. Always prioritize a balanced diet and healthy lifestyle alongside any supplementation for optimal results.

testosterone for ed 4

Psychological and Emotional Factors in ED

Erectile dysfunction (ED) is not just a physical problem; it is also deeply connected to psychological and emotional factors. Understanding these aspects is crucial for effective treatment. This section explores how stress, anxiety, depression, and other emotional issues can contribute to ED and discusses ways to manage these psychological factors.

Stress and ED

Stress is a common issue in today's fast-paced world. When a person is stressed, their body releases hormones like cortisol and adrenaline. These hormones can affect the way blood flows in the body, including to the penis. Blood flow is essential for achieving and maintaining an erection, so when stress interferes, it can lead to ED.

Stress can come from various sources such as work, relationships, financial problems, or health concerns. Chronic stress, which lasts for a long time, is particularly harmful because it keeps the body in a constant state of tension. This constant tension can reduce sexual desire and make it harder to perform sexually.

Anxiety and ED

Anxiety is another significant factor that can cause or worsen ED. Anxiety about sexual performance, in particular, is very common. Men may worry about their ability to perform well in bed, which creates a cycle of fear and failure. This type of anxiety is known as performance anxiety.

Performance anxiety can cause the release of stress hormones, which as mentioned, interfere with blood flow. This can prevent an erection from occurring or make it difficult to maintain. The more a man worries about his sexual performance, the more likely he is to experience ED, creating a vicious cycle.

Depression and ED

Depression is a mental health condition that can severely affect a person's quality of life, including their sexual health. Depression often leads to a loss of interest in activities that were once enjoyable, including sex. It can also result in fatigue, feelings of worthlessness, and a lack of energy, all of which can contribute to ED.

Moreover, depression can alter the levels of neurotransmitters in the brain. Neurotransmitters are chemicals that send signals between nerve cells. When their balance is disrupted, it can affect mood, energy levels, and sexual function. Antidepressant medications, which are commonly used to treat depression, can also have side effects that include ED.

Relationship Issues and ED

Problems in a relationship can also lead to ED. Communication problems, unresolved conflicts, and lack of intimacy can all contribute to stress and anxiety, which in turn can cause ED. When a couple is not emotionally connected, it can be difficult for them to connect physically.

ED can also create a strain on a relationship, as both partners may feel frustrated, rejected, or inadequate. This can lead to further emotional distance and increased stress, perpetuating the problem.

Managing Psychological Factors

Addressing psychological factors is crucial in treating ED. Here are some strategies that can help:

Counseling and Therapy

Seeing a mental health professional can be very beneficial. Therapy can help identify and address the underlying psychological issues contributing to ED. Cognitive-behavioral therapy (CBT), for example, can help change negative thought patterns and behaviors related to sex.

Stress Management Techniques

Learning how to manage stress is essential. Techniques such as deep breathing exercises, meditation, yoga, and mindfulness can help reduce stress levels. Regular physical exercise is also an excellent way to manage stress and improve overall well-being.

Open Communication

Improving communication with a partner can help address relationship issues. Talking openly about fears, expectations, and concerns can reduce misunderstandings and increase emotional intimacy. Couples therapy can also be beneficial in resolving conflicts and improving relationship dynamics.

Healthy Lifestyle Choices

Adopting a healthy lifestyle can have a positive impact on mental health. Eating a balanced diet, getting regular exercise, ensuring adequate sleep, and avoiding excessive alcohol and drug use can improve both physical and emotional well-being.

Psychological and emotional factors play a significant role in ED. Stress, anxiety, depression, and relationship problems can all contribute to the condition. Managing these factors through therapy, stress management techniques, open communication, and healthy lifestyle choices can help improve erectile function and overall quality of life. Understanding and addressing the psychological aspects of ED is crucial for effective treatment and long-term sexual health.

Emerging Treatments and Research

Emerging treatments and ongoing research offer hope for those struggling with erectile dysfunction (ED) and low testosterone. These new approaches aim to improve outcomes and provide more options for men facing these issues. Understanding the latest developments can help patients and healthcare providers make informed decisions about treatment.

Advances in Medical Treatments for ED and Low Testosterone

Medical science continually seeks better ways to treat ED and low testosterone. Some of the latest advances include:

  1. Selective Androgen Receptor Modulators (SARMs)
    • SARMs are drugs that mimic testosterone. They bind to androgen receptors in the body, which can help increase muscle mass and improve sexual function. Unlike traditional testosterone replacement therapy (TRT), SARMs may have fewer side effects and target specific tissues.
  2. Gene Therapy
    • Gene therapy is a cutting-edge approach that involves altering genes to treat or prevent diseases. For ED, researchers are exploring ways to use gene therapy to improve blood flow to the penis or increase the body's natural production of nitric oxide, a chemical that helps achieve and maintain erections.
  3. Stem Cell Therapy
    • Stem cells are special cells that can develop into many different types of cells in the body. Researchers are investigating whether stem cell therapy can repair damaged tissues and improve erectile function. Early studies show promise, but more research is needed to confirm the safety and effectiveness of this treatment.
  4. Platelet-Rich Plasma (PRP) Therapy
    • PRP therapy involves injecting a concentration of a patient's own platelets into the penis. The goal is to promote tissue growth and improve blood flow. Some studies suggest that PRP therapy may help men with ED, but further research is required to establish its benefits and risks.
  5. Low-Intensity Extracorporeal Shockwave Therapy (LI-ESWT)
    • LI-ESWT uses sound waves to stimulate blood flow and promote the formation of new blood vessels in the penis. This non-invasive treatment has shown promise in improving erectile function, especially in men who do not respond well to traditional ED medications.

Experimental Therapies and Ongoing Research

  1. New Medications
    • Researchers are constantly developing and testing new medications for ED and low testosterone. These include new types of PDE5 inhibitors, like those found in Viagra and Cialis, as well as entirely new classes of drugs. These medications aim to improve effectiveness, reduce side effects, and offer alternatives for men who do not respond to existing treatments.
  2. Hormonal Therapies
    • In addition to TRT, scientists are exploring other hormonal therapies that could help men with low testosterone and ED. For example, treatments that target specific pathways in the brain or other hormones involved in sexual function may provide new options for patients.
  3. Bioelectric Therapy
    • Bioelectric therapy uses electrical stimulation to improve nerve function and blood flow. This approach is still in the experimental stage, but early results suggest it may help some men with ED, particularly those with nerve damage or poor blood circulation.
  4. Personalized Medicine
    • Personalized medicine tailors treatment to the individual patient's genetic makeup, lifestyle, and specific health conditions. This approach could lead to more effective and targeted therapies for ED and low testosterone, reducing the trial-and-error process often associated with finding the right treatment.

Future Directions in Treatment and Management

The future of ED and low testosterone treatment looks promising, with many potential advancements on the horizon. Key areas of focus include:

  1. Improving Accessibility and Affordability
    • As new treatments are developed, making them accessible and affordable for all patients is crucial. This includes ensuring that cutting-edge therapies are covered by insurance and available in a variety of healthcare settings.
  2. Increasing Awareness and Education
    • Educating both healthcare providers and patients about the latest treatments and research can help improve outcomes. This includes training doctors on new therapies and providing patients with reliable information to make informed decisions about their care.
  3. Enhancing Patient Support
    • Comprehensive care for ED and low testosterone involves more than just medical treatment. Providing support for mental health, lifestyle changes, and relationship counseling can help patients achieve better overall outcomes.

Emerging treatments and ongoing research offer hope for men with ED and low testosterone. Advances in medical treatments, experimental therapies, and personalized medicine are paving the way for more effective and tailored approaches. As the field continues to evolve, patients can look forward to improved options and better management of their conditions.

Preventive Measures and Long-term Management

Maintaining good health and managing conditions like erectile dysfunction (ED) and low testosterone are ongoing processes. Taking preventive measures and having a long-term management plan can help you lead a healthy life and reduce the impact of these issues. Here are some key steps to consider:

Regular Medical Check-ups and Monitoring

Regular visits to your doctor are crucial. During these visits, your doctor can check your testosterone levels and monitor other health indicators. They can also assess your overall health and address any concerns you might have.

Why It's Important:

  • Early Detection: Regular check-ups can help catch any issues early before they become serious problems.
  • Customized Advice: Your doctor can give you advice based on your personal health history and current condition.
  • Ongoing Support: Regular visits allow your doctor to monitor your progress and adjust treatments as needed.

Importance of a Healthy Lifestyle for Maintaining Testosterone Levels

A healthy lifestyle can have a big impact on your testosterone levels and overall health. Here are some key aspects to focus on:

Diet and Nutrition:

  • Balanced Diet: Eating a variety of foods can help ensure you get all the nutrients you need. Focus on fruits, vegetables, whole grains, lean proteins, and healthy fats.
  • Foods to Boost Testosterone: Some foods are particularly good for boosting testosterone levels. These include leafy greens, fatty fish, nuts, seeds, and eggs.

Exercise and Physical Activity:

  • Regular Exercise: Aim for at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous activity each week. Include strength training exercises at least twice a week.
  • Types of Exercise: Both aerobic exercises like running or swimming and strength training like lifting weights can help boost testosterone levels.

Weight Management:

  • Healthy Weight: Maintaining a healthy weight is important. Being overweight or obese can lead to lower testosterone levels and increase the risk of ED.
  • Strategies for Weight Loss: If you need to lose weight, focus on a balanced diet and regular physical activity. Set realistic goals and track your progress.

Avoiding Harmful Habits:

  • Smoking: Smoking can lower testosterone levels and increase the risk of ED. If you smoke, seek help to quit.
  • Alcohol: Drinking too much alcohol can also lower testosterone levels. Try to limit your intake to moderate levels.
  • Drug Use: Avoiding recreational drugs is important for maintaining healthy testosterone levels.

Long-term Strategies for Managing ED

Managing ED is an ongoing process. Here are some strategies to consider for long-term management:

Medications:

  • Consistency: If you are prescribed medications like phosphodiesterase type 5 inhibitors (e.g., Viagra, Cialis), take them as directed by your doctor.
  • Communication: Keep your doctor informed about how the medications are working and any side effects you experience.

Psychological Support:

  • Counseling: Psychological factors like stress, anxiety, and depression can contribute to ED. Consider seeing a counselor or therapist to address these issues.
  • Support Groups: Joining a support group can help you connect with others who are going through similar experiences.

Relationship Health:

  • Communication with Partner: Open and honest communication with your partner about your condition can help reduce stress and improve your relationship.
  • Couples Counseling: In some cases, couples counseling can be beneficial for both partners.

Alternative Therapies:

  • Acupuncture: Some people find that acupuncture helps with ED symptoms.
  • Herbal Remedies: While more research is needed, some herbal remedies may help with ED. Always talk to your doctor before trying any new treatments.

Making Health a Priority

Taking care of your overall health is important for managing ED and low testosterone. This includes:

  • Regular Exercise: Staying active helps keep your body in good condition.
  • Healthy Eating: A nutritious diet supports all aspects of your health.
  • Sleep: Getting enough rest is crucial. Aim for 7-9 hours of sleep per night.
  • Stress Management: Find healthy ways to manage stress, such as meditation, yoga, or hobbies.

Taking preventive measures and having a long-term management plan can make a big difference in managing ED and low testosterone. By working with your doctor, making healthy lifestyle choices, and seeking support when needed, you can lead a healthy and fulfilling life. Regular check-ups, a balanced diet, regular exercise, and addressing psychological factors are all important steps in maintaining your health and well-being.

Conclusion

In this article, we have explored the intricate relationship between testosterone and erectile dysfunction (ED). Understanding this connection is essential for those affected by ED, as it offers insights into effective treatments and natural solutions that can significantly improve quality of life.

We began by defining erectile dysfunction, a common condition that affects many men worldwide. ED is characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. This condition can arise from a variety of causes, including physical, psychological, and lifestyle factors. It's important to recognize that ED is not just a physical issue; it can also profoundly impact mental health and well-being, leading to stress, anxiety, and a diminished quality of life.

Testosterone plays a crucial role in male sexual health. It is a hormone responsible for the development of male sexual characteristics and is vital for maintaining libido and erectile function. Testosterone levels naturally decline with age, which can lead to decreased sexual desire and performance. Understanding how testosterone influences sexual health is key to addressing issues related to ED.

Low testosterone, or hypogonadism, can result from various medical conditions and lifestyle choices. Primary hypogonadism occurs when the testes do not produce sufficient testosterone, while secondary hypogonadism is due to problems in the brain's regulatory centers. Symptoms of low testosterone include fatigue, depression, reduced muscle mass, and, notably, decreased sexual desire and erectile dysfunction. Identifying these symptoms and their underlying causes is the first step in seeking appropriate treatment.

Diagnosing low testosterone and ED involves a thorough medical evaluation. This includes discussing symptoms with a healthcare provider, undergoing physical examinations, and conducting laboratory tests to measure hormone levels. Differentiating between primary and secondary causes of low testosterone is crucial for determining the most effective treatment approach.

For many men, medical treatments offer a viable solution to low testosterone and ED. Testosterone replacement therapy (TRT) is a common treatment that involves supplementing the body with testosterone through injections, gels, patches, or other methods. TRT can effectively improve symptoms of low testosterone, including sexual dysfunction. Another class of medications, phosphodiesterase type 5 inhibitors (PDE5 inhibitors), such as Viagra, Cialis, and Levitra, can enhance erectile function by increasing blood flow to the penis. These medications are often used in conjunction with TRT or other treatments to maximize effectiveness.

Lifestyle changes can also play a significant role in managing testosterone levels and improving ED. A balanced diet rich in essential nutrients, regular physical activity, and maintaining a healthy weight are all critical components. Certain foods, such as those high in zinc and vitamin D, can naturally boost testosterone levels. Exercise, particularly strength training and high-intensity interval training (HIIT), has been shown to enhance testosterone production. Additionally, weight management is crucial, as obesity is linked to lower testosterone levels and increased risk of ED.

Natural supplements, including herbal remedies like ginseng, fenugreek, and ashwagandha, and essential vitamins and minerals, may offer additional support. While the efficacy of these supplements can vary, they are generally considered safe when used appropriately. Consulting with a healthcare provider before starting any supplement regimen is recommended to ensure safety and effectiveness.

Psychological and emotional factors, such as stress, anxiety, and depression, can significantly impact erectile function and testosterone levels. Addressing these factors through counseling, therapy, and stress management techniques can improve overall sexual health. Understanding and managing the psychological aspects of ED is an integral part of a comprehensive treatment approach.

Emerging treatments and ongoing research continue to advance our understanding and management of ED and low testosterone. New therapies and experimental treatments offer hope for more effective solutions in the future. Staying informed about these developments and discussing potential options with a healthcare provider can help individuals make informed decisions about their treatment.

Preventive measures and long-term management strategies are essential for maintaining healthy testosterone levels and preventing ED. Regular medical check-ups, adopting a healthy lifestyle, and staying proactive about sexual health are vital. By taking these steps, men can improve their overall well-being and reduce the risk of developing ED.

In conclusion, addressing the complex relationship between testosterone and ED requires a multifaceted approach. From medical treatments and lifestyle changes to natural supplements and psychological support, a comprehensive strategy is essential. Seeking medical advice and staying informed about the latest developments in ED and testosterone treatments can lead to better outcomes and an improved quality of life.

Questions and Answers

Research Citations

Sources
Share this article

Corona, G., Rastrelli, G., Reisman, Y., Sforza, A., Maggi, M., & Mannucci, E. (2014). Testosterone and erectile dysfunction: An unresolved enigma. International Journal of Impotence Research, 26(2), 58-61. doi:10.1038/ijir.2014.2

Traish, A. M., & Mulgaonkar, A. (2014). The link between testosterone and erectile dysfunction: Evidence for the existence of a functional androgen receptor in penile tissue. Sexual Medicine Reviews, 2(3), 88-101. doi:10.1002/smrj.22

Hackett, G., Cole, N., & Bhartia, M. (2013). Testosterone replacement therapy with long-acting testosterone undecanoate improves sexual function and quality-of-life parameters vs. placebo in a population of men with type 2 diabetes. Journal of Sexual Medicine, 10(6), 1612-1627. doi:10.1111/jsm.12163

Yassin, A. A., Nettleship, J., & Almehmadi, Y. (2007). Testosterone and erectile function: From basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction. Journal of Sexual Medicine, 4(4 Pt 1), 1117-1124. doi:10.1111/j.1743-6109.2007.00495.x

Spitzer, M., Basaria, S., Travison, T. G., Davda, M. N., Paley, A., Cohen, B., … Bhasin, S. (2013). Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: A parallel, randomized trial. Annals of Internal Medicine, 158(9), 581-590. doi:10.7326/0003-4819-158-9-201305070-00006

Traish, A. M., Haider, A., Haider, K. S., Doros, G., & Saad, F. (2014). Long-term testosterone therapy improves cardiometabolic function and reduces risk of cardiovascular disease in men with hypogonadism and erectile dysfunction. Journal of Sexual Medicine, 11(2), 156-166. doi:10.1111/jsm.12365

Khera, M., Bhattacharya, R. K., Blick, G., Kushner, H., Nguyen, D., & Miner, M. M. (2011). Improved sexual function with testosterone replacement therapy in hypogonadal men: Real-world data from a urological practice. Journal of Sexual Medicine, 8(11), 3204-3213. doi:10.1111/j.1743-6109.2011.02361.x

Isidori, A. M., Giannetta, E., Gianfrilli, D., Greco, E. A., Bonifacio, V., Aversa, A., … Lenzi, A. (2005). Effects of testosterone on sexual function in men: Results of a meta-analysis. Clinical Endocrinology, 63(4), 381-394. doi:10.1111/j.1365-2265.2005.02378.x

Yassin, A. A., Saad, F., & Traish, A. (2006). Testosterone undecanoate restores erectile function in a subset of patients with venous leakage: A series of case reports. Journal of Sexual Medicine, 3(4), 727-735. doi:10.1111/j.1743-6109.2006.00297.x

Hackett, G., Cole, N., & Saghir, A. (2014). Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with erectile dysfunction: A review of the literature. International Journal of Clinical Practice, 68(9), 1127-1136. doi:10.1111/ijcp.12466