Erectile dysfunction (ED) is a common side effect of antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs). This is thought to be due to the way that antidepressants affect the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine Serotonin is a neurotransmitter that plays a role in regulating mood and sexual function. …